IGF-DES

(Des-IGF-1) IGF-DES is a truncated, synthetic analog of Insulin-like Growth Factor-1 (IGF-1), lacking the first three N-terminal amino acids: glutamic acid, glycine, and proline. This modification: Increases IGF-1 receptor binding affinity ~10x compared to native IGF-1 Reduces half-life to 20–30 minutes (versus several hours for native IGF-1) Bypasses IGF-binding proteins (IGFBPs), ensuring 100% bioavailability at the injection site Mechanism of Action Activates PI3K/Akt/m TOR and MAPK/ERK pathways Stimulates satellite cell activation, muscle hypertrophy, and collagen synthesis Short half-life allows precise, localized effects without systemic distribution