CJC-1295 DAC

CJC-1295 with DAC is a synthetic analog of growth hormone–releasing hormone (GHRH) designed to provide longlasting stimulation of growth hormone (GH) secretion. The peptide contains amino acid modifications that improve stability, plus a Drug Affinity Complex (DAC) that binds to albumin in the bloodstream. This extends its half-life from about 30 minutes to nearly a week, allowing once-weekly or biweekly dosing. CJC-1295 activates GHRH receptors on pituitary cells, triggering a sustained rise in GH and insulin-like growth factor 1 (IGF-1). Clinical studies show GH levels can increase 2–10 fold and IGF-1 levels rise 1.5–3 fold, with effects lasting up to 11 days after a single dose. Unlike natural GHRH, which works in short pulses, CJC-1295 provides continuous stimulation, supporting muscle growth, tissue repair, metabolism, and recovery.