5-Amino-1MQ

5-Amino-1MQ is a novel small-molecule compound designed to target nicotinamide N-methyltransferase (NNMT), an enzyme crucial in metabolic regulation. By specifically inhibiting NNMT, this compound aims to rebalance key cellular energy pathways. This action helps to increase levels of NAD⁺ and Sadenosylmethionine (SAM) while reducing a byproduct called 1methylnicotinamide. This metabolic adjustment is intended to support healthier mitochondrial function and improve the body's ability to burn fat. Preclinical studies have shown that 5Amino-1MQ is highly cell-permeable and effectively targets NNMT, leading to significant anti-obesity effects in animal models without affecting food intake or causing noticeable side effects.